Commentary on the role of berberine in addition to methimazole compare to methimazole alone in the treatment of Graves’ Diseas

Graves’ Disease (GD) is the most common form of hyperthyroidism. It affects 3% female patients and 0.5% male usually between age 30-60. cause 80% hyperthyroid cases in USA. The pathogenesis disease complex autoimmunity plays a key role. antibodies stimulating thyrotropin receptor (TRAb) lead to uncontrolled Thyroid-stimulating Hormone (TSH) overproduction thyroid hormones from overactive gland. frequently associated with Graves's ophthalmopathy, dermatopathy, clubbing. whole body deleterious effects on Cardiovascular system, vision, bones, etc. treatment anti-thyroid medications, Radioactive iodine, or surgery each one which has its pluses minuses. Other factors like Genetic, inflammatory, immune, environmental factors, play critical roles as well. In this article, we are discussing newfound role gut-thyroid axis GD. We describing probiotic Berberine added medication Methimazole changing gut microbiota by increasing benefits decreasing bacteria gut. This can induction anti-inflammatory cytokines reduction inflammatory ones regulate immune system faster better than alone. combination eventually through effect disappearance TRAb remission cure